Penicillin-acylase

EC 3.5.1.11

Amidases

from genetically modified Escherichia coli

Application: Penicillin-acylase is an enzyme that cleaves Penicillin G into 6-aminopenicillanic acid (6-APA) and phenylacetic acid. Synthesis of unnatural penicillin by coupling 6-aminopenicillanic acid with a selected side chain (e.g. Methicillin, Ampicillin, Pheneticillin). Used for semisynthetic penicillin production.

Activity: > 750 U/mL

Article No.: 2605

Product data sheet DE: PenAc – 2605 – DE

Product data sheet ENG: PenAc – 2605 – ENG

Material safety data sheet: On inquiry

Scientific literature: 

Penicillin acylases revisited: importance beyond their industrial utility (By Vellore Sunder Avinash, Archana Vishnu Pundle, et al; 2014; Crit Rev Biotechnol., Volume 36, Issue 2, November 2014, Pages 303-316; DOI: 10.3109/07388551.2014.960359)

13 – Industrial and Therapeutic Enzymes: Penicillin Acylase (By A. Illanes, P. Valencia; 2016; Current Developments in Biotechnology and Bioengineering, Elsevier, 2017, Pages 267-305; DOI: 10.1016/B978-0-444-63662-1.00013-0)